Hematopoietic growth factors pass through the blood–brain barrier in intact rats
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چکیده
منابع مشابه
Hematopoietic growth factors
Erythropoietin is a lineage-specific distal-acting factor that stimulates maturation of committed erythroid progenitors to become mature erythrocytes.3 Carbohydrates, rich in sialic acid, make up 30% to 40% of the 34,000-Da molecule and are essential for its secretion, stability in the circulation, and biologic activity. Many earlier-acting factors, including stem cell factor/kit ligand, interl...
متن کامل[Hematopoietic growth factors].
Haematopoietic growth factors are a family of genetically determined low molecular weight glycoproteins which regulate the proliferation and differentiation of haemopoietic cells through specific membrane receptors. GCSF and GMCSF reduce the morbidity from infections associated with the neutropenia induced by chemotherapy of onco-haematological neoplasia; EPQ totally corrects not only the anaem...
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Abbreviations: acute myeloid leukemia, (AML); American Society of Clinical Oncology, (ASCO); bone marrow, (BM); end stage renal disease, (ESRD); erythropoietin, (EPO); granulocyte colony-stimulating factor, (G-CSF); Granulocyte-macrophage colony-stimulating factor, (GM-CSF); hematopoietic growth factors, (HGFs); hematopoietic stem cell, (HSC); hemoglobin, (Hgb); idiopathic thrombocytopenic purp...
متن کاملHematopoietic growth factors in myelodysplastic syndromes.
Hematopoietic growth factors (HGFs) continue to be the most widely prescribed class of medications for patients with myelodysplastic syndromes (MDS), despite the advent of disease-modifying therapies for MDS (eg, azacitidine, decitabine, and lenalidomide) and the current absence of an MDS-specific US Food and Drug Administration (FDA)-approved indication for any of the HGFs. Erythropoiesis-stim...
متن کاملHematopoietic growth factors in drug-induced agranulocytosis.
Drug-induced agranulocytosis (DIA) is a potentially fatal disorder. Hematopoietic growth factors have been used in the treatment of DIA. We report nine cases of DIA treated with granulocyte macrophage - colony stimulating factor (GM-CSF) in a dose of 300 microg/day. All the patients had evidence of systemic infection. Mean time to reach an absolute neutrophil count of 0.5 x 10(9)/L was three da...
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ژورنال
عنوان ژورنال: Experimental Neurology
سال: 2007
ISSN: 0014-4886
DOI: 10.1016/j.expneurol.2006.12.001